Franco Tagliaro

2 papers in the library · 74 citations · publishing 1998-2018

Papers

Simultaneous chiral separation of 3,4‐methylenedioxymethamphetamine (MDMA), 3‐4‐methylenedioxyamphetamine (MDA), 3,4‐methylenedioxyethylamphetamine (MDE), ephedrine, amphetamine and methamphetamine by capillary electrophoresis in uncoated and coated capillaries with native β‐cyclodextrin as the chiral selector: Preliminary application to the analysis of urine and hair

Electrophoresis January 1, 1998 Franco Tagliaro, Giulia Manetto, Silvana Bellini et al. 74 citations

A capillary electrophoresis method using native β-cyclodextrin as a chiral selector simultaneously separates and detects the enantiomers of six amphetamine-related substances: ephedrine, amphetamine, methamphetamine, MDMA, MDA, and MDE. Optimized conditions (pH 2.5 phosphate buffer, uncoated capillary, 10 kV) achieve good resolution and chiral selectivity for all analytes. Detection limits are better than 0.2 μg/mL, with high precision (intra-day migration time relative standard deviation < 0.8%) and linearity from 0.156 to 40 μg/mL. After liquid-liquid extraction, urine samples can be analyzed below the 500 ng/mL NIDA cut-off. For hair samples, field-amplified sample stacking enables chiral determination of MDMA, MDA, and MDE at concentrations found in real ecstasy users.

DOI: 10.1002/elps.1150190109 Capillary electrophoresis Chromatography Chemistry Pseudoephedrine +4

Neurological, sensorimotor and cardiorespiratory alterations induced by methoxetamine, ketamine and phencyclidine in mice.

Neuropharmacology October 1, 2018 Andrea Ossato, Sabrine Bilel, Adolfo Gregori et al.

Methoxetamine (MXE), a dissociative drug similar to ketamine and phencyclidine, alters neurological and sensorimotor functions in mice in a dose-dependent manner. Acute systemic administration of MXE, ketamine, and phencyclidine (0.01–30 mg/kg i.p.) differentially affected visual, acoustic, and tactile responses, thermal and mechanical pain, motor activity, and acoustic startle reactivity. MXE and ketamine (1 and 30 mg/kg i.p.) and phencyclidine (1 and 10 mg/kg i.p.) also significantly affected cardiorespiratory parameters and systolic and diastolic blood pressure. The findings suggest MXE produces effects comparable to its parent compounds, with specificity depending on dose and parameter examined.

DOI: 10.1016/j.neuropharm.2018.08.017 Full text Ketamine Behavioral alterations Dissociative drugs Methoxetamine +1