Analysis of MDMA and its Metabolites in Urine and Plasma Following a Neurotoxic Dose of MDMA
Journal of Analytical Toxicology April 1, 2007 Sandra Valtier, Clyde F. Phelix, John T. Cody 14 citations
After a single neurotoxic dose (20 mg/kg) of MDMA given to male Dark Agouti rats, the drug and three of its metabolites—MDA, HMMA, and HMA—appeared in urine at different peak times: MDMA at 4 hours, MDA at 8 hours, HMMA at 12 hours, and HMA at 16 hours. All four compounds remained detectable in urine for up to 168 hours (detection limit 25 ng/mL). In plasma, MDMA and MDA peaked at 2 hours, HMMA at 4 hours, and HMA at 24 hours, but with high variability at that time point. No MDMA or metabolites were detectable in plasma at 96 or 168 hours (detection limit 10 ng/mL).