Stereoselective pharmacokinetics of 3,4‐methylenedioxymethamphetamine in the rat
Chirality January 1, 1990 Robert L. Fitzgerald, Robert V. Blanke, Alphonse Poklis 50 citations
The pharmacokinetics of MDMA enantiomers were studied in rats using iliac arterial cannulation. Intravenous and subcutaneous routes were tested at two dose levels each. The average half-life for (−)-(R)-MDMA was 2.5 ± 0.8 hours and for (+)-(S)-MDMA was 2.2 ± 0.8 hours. (+)-(S)-MDMA was cleared more rapidly than (−)-(R)-MDMA, consistent with area under the curve data for the parent drug and its primary metabolite MDA. The mean AUC S/R ratios for MDMA and MDA were 0.70 ± 0.05 and 3.1 ± 0.8, respectively. After a 20 mg/kg intravenous dose, the percent dose excreted as (−)-(R)-MDMA, (+)-(S)-MDMA, (−)-(R)-MDA, and (+)-(S)-MDA were 20 ± 10, 12 ± 6, 3 ± 1, and 6 ± 2, respectively.