Journal of Psychoactive Drugs
October 20, 2014
Joji Suzuki, Justin L. Poklis, Alphonse Poklis
60 citations
A case report describes a suicide attempt following ingestion of a substance believed to be LSD, but laboratory analysis identified it as 25I-NBOMe, a synthetic hallucinogen of the NBOMe class. The authors emphasize that clinicians should suspect NBOMe ingestion in patients who report recent use of LSD or other hallucinogens, as adverse effects are increasingly reported.
Chirality
January 1, 1990
Robert L. Fitzgerald, Robert V. Blanke, Alphonse Poklis
50 citations
The pharmacokinetics of MDMA enantiomers were studied in rats using iliac arterial cannulation. Intravenous and subcutaneous routes were tested at two dose levels each. The average half-life for (−)-(R)-MDMA was 2.5 ± 0.8 hours and for (+)-(S)-MDMA was 2.2 ± 0.8 hours. (+)-(S)-MDMA was cleared more rapidly than (−)-(R)-MDMA, consistent with area under the curve data for the parent drug and its primary metabolite MDA. The mean AUC S/R ratios for MDMA and MDA were 0.70 ± 0.05 and 3.1 ± 0.8, respectively. After a 20 mg/kg intravenous dose, the percent dose excreted as (−)-(R)-MDMA, (+)-(S)-MDMA, (−)-(R)-MDA, and (+)-(S)-MDA were 20 ± 10, 12 ± 6, 3 ± 1, and 6 ± 2, respectively.
Journal of Forensic Sciences
January 1, 1979
Alphonse Poklis, Mary Ann Mackell, Wk Drake
25 citations
MDA is a potent central nervous system stimulant with effects similar to both amphetamine and mescaline. It causes peripheral vasoconstriction, tachycardia, pupillary dilation, and at high doses can lead to convulsions, hyperthermia, and behavioral changes. The 3,4-methyleneoxy group gives it psychopharmacological properties like mescaline. At a threshold dose of 80 mg, it produces marked perceptual distortions starting about 60 minutes after oral ingestion and lasting up to 8 hours. Subjective effects include intensified feelings, self-insight, and a strong desire to communicate. High doses may cause hallucinations.
Clinical Chemistry
May 1, 1988
José Manuel Ramos, R.l. Fitzgerald, Alphonse Poklis
10 citations
The Abbott TDx amphetamine/methamphetamine reagents show cross-reactivity with MDMA and MDA, meaning these drugs can produce false-positive results when testing for amphetamines. This finding has implications for forensic toxicology and clinical drug testing, as it may lead to misidentification of substances.