Concomitant drugs associated with increased mortality for MDMA users reported in a drug safety surveillance database
Scientific Reports March 16, 2021 Isaac Cohen, Tigran Makunts, Ruben Abagyan et al. 30 citations
Using FDA drug safety surveillance data, nearly one thousand reports of MDMA use were analyzed to evaluate risks of death when MDMA is taken alone or with other medications. Several drug classes—including MDMA metabolites or analogs, anesthetics, muscle relaxants, amphetamines and stimulants, benzodiazepines, ethanol, and opioids—along with the antidepressants bupropion, sertraline, venlafaxine, and citalopram, and the antipsychotic olanzapine, showed increased odds ratios for reported risk of death. The authors call for future clinical trials to assess whether these drug–drug interactions pose actual harm in controlled medical settings.