Application of the Syva EMIT and Abbott TDx Amphetamine Immunoassays to the Detection of 3,4-Methylenedioxymethamphetamine (MDMA) and 3,4-Methylenedioxyethamphetamine (MDEA) in Urine
Journal of Analytical Toxicology May 1, 1990 Gary W. Kunsman, Joseph E. Manno, K.r. Cockerham et al. 34 citations
MDMA and MDEA, hallucinogenic amphetamine analogs, are increasingly used recreationally, prompting evaluation of common urine drug tests. The Abbott TDx and Syva EMIT-d.a.u. amphetamine immunoassays were tested for cross-reactivity with MDMA- and MDEA-spiked urine samples. The Syva EMIT assay detected only the highest concentration (10.0 micrograms/mL) of both substances. The TDx assay showed cross-reactivity for MDMA ranging from 18% at high concentrations to 118% at low concentrations, and for MDEA from 12% to 47%. Precision for TDx was good, with coefficients of variation below 6% for MDMA. Negative EMIT but positive TDx results were confirmed by GC/MS.