Evaluation of a Rapid Oral Fluid Point-of-Care Test for MDMA
Journal of Analytical Toxicology March 1, 2007 Lisa Wilson, Ahmed Jehanli, C. W. Hand et al. 15 citations
A new lateral flow test (Cozart RapiScan System) detects MDMA and methamphetamine in oral fluid with high accuracy. Among 370 oral fluid samples, 121 screened positive. Using a 45 ng/mL screening cutoff and 30 ng/mL confirmation cutoff, sensitivity was 96.6%, specificity 96.8%, and accuracy 96.8%. The test also cross-reacts with high levels of amphetamine, causing six false positives. Applying a 50 ng/mL confirmation cutoff improved sensitivity to 98.3%, specificity to 96.9%, and accuracy to 97.3%. Confirmatory testing by gas chromatography-mass spectrometry identified multiple amphetamines.