Urinary Excretion Profiles of 5-Methoxy-N,N-diisopropyltryptamine and Its Relevant Metabolites in Humans
JOURNAL OF HEALTH SCIENCE January 1, 2007 Tooru Kamata, Munehiro Katagi, Hiroe Kamata et al. 4 citations
In urine from six users of the psychedelic tryptamine 5-MeO-DIPT, three metabolites—5-OH-DIPT, 6-OH-5-MeO-DIPT, and 5-MeO-NIPT—were identified. Using enzymatic hydrolysis with ascorbic acid to prevent degradation, conjugated forms (sulfates and glucuronides) of the hydroxylated metabolites were fully cleaved, greatly increasing their detection, especially for 6-OH-5-MeO-DIPT. After hydrolysis, concentrations of 5-OH-DIPT ranged from 0.01 to 47 μg/ml and 6-OH-5-MeO-DIPT up to 69 μg/ml, while the parent drug and 5-MeO-NIPT remained below 1.7 and 3.5 μg/ml, respectively. Metabolites were detectable longer than the parent compound: 5-OH-DIPT up to 80 hours, 6-OH-5-MeO-DIPT and 5-MeO-NIPT up to 60 hours, versus 35 hours for 5-MeO-DIPT.