Effect of Low-Dose Esketamine Combined with Propofol on Postoperative Fatigue in Colonoscopy: A Randomized Clinical Trial.
Therapeutics and clinical risk management January 1, 2025 Xuemei Sun, Qiuling Du, Yongjie Liang et al. 5 citations
Postoperative fatigue is common after colonoscopy, linked to bowel preparation and the procedure itself. In a randomized trial, 151 patients received either low-dose esketamine (0.15 mg/kg) or sufentanil (0.1 μg/kg) before anesthesia. Esketamine reduced the incidence of postoperative fatigue from 44% to 28% at 30 minutes after the procedure, and shortened discharge time from 30 to 25 minutes. Hemodynamic stability and patient satisfaction were also better with esketamine. The findings suggest that adding esketamine to propofol anesthesia is an effective strategy for painless colonoscopy.