Journal of clinical anesthesia
April 1, 2025
Qingfeng Wei, Mengmeng Li, Qiuling Du et al.
10 citations
A single dose of 0.25 mg/kg esketamine given during breast cancer surgery did not significantly increase the proportion of women who achieved a 50% reduction in depression scores within three days after surgery. Among 104 women with preoperative depressive symptoms, 27% in the esketamine group reached this threshold versus 13% in the placebo group, a difference that was not statistically significant. However, esketamine did produce significantly lower depression scores on postoperative days one through five, with a mean additional decrease of 2.5 points on the Montgomery-Åsberg scale compared to placebo. No significant effects were seen on anxiety, pain, or adverse events.
BMJ Open
September 25, 2023
Cen Chen, Qingfeng Wei, Jiajia Zhu et al.
7 citations
A planned trial will test whether a low dose of the anesthetic esketamine, given before and during surgery, reduces depressive symptoms in women with breast cancer who are undergoing radical mastectomy. The study will randomly assign 108 women with mild-to-severe depression to receive either esketamine or a saline placebo. The main outcome is the proportion of patients whose depressive symptoms improve by the third day after surgery. The study also will measure changes in a brain protein called brain-derived neurotrophic factor and in resting-state brain connectivity, aiming to uncover how esketamine might work.
Therapeutics and clinical risk management
January 1, 2025
Xuemei Sun, Qiuling Du, Yongjie Liang et al.
5 citations
Postoperative fatigue is common after colonoscopy, linked to bowel preparation and the procedure itself. In a randomized trial, 151 patients received either low-dose esketamine (0.15 mg/kg) or sufentanil (0.1 μg/kg) before anesthesia. Esketamine reduced the incidence of postoperative fatigue from 44% to 28% at 30 minutes after the procedure, and shortened discharge time from 30 to 25 minutes. Hemodynamic stability and patient satisfaction were also better with esketamine. The findings suggest that adding esketamine to propofol anesthesia is an effective strategy for painless colonoscopy.
Drug Design Development and Therapy
March 1, 2026
Meng-Meng Li, Qingfeng Wei, Qian-Yun Zhu et al.
Combining low-dose dexmedetomidine with esketamine during cesarean section improves early postpartum depressive symptoms, reduces neuropsychiatric side effects during surgery, and increases maternal satisfaction, while remaining safe for both mother and newborn.