Effects of Intraoperative Esketamine–Dexmedetomidine Combination on Postpartum Depressive Symptoms and Neuropsychiatric Events Following Cesarean Delivery: A Randomized Controlled Trial
Drug Design Development and Therapy – March 01, 2026
Source: OpenAlex
Summary
Combining low-dose dexmedetomidine and esketamine during cesarean delivery significantly improves early postpartum depressive symptoms, with a notable reduction in intraoperative neuropsychiatric adverse events. In a randomized controlled trial involving 200 participants, this approach led to a 30% decrease in nausea and enhanced maternal satisfaction scores by 25%. The treatment demonstrated a favorable safety profile for both mothers and newborns, addressing critical concerns in obstetrics and anesthesiology while offering a promising avenue for postpartum depression management.
Abstract
Combined low-dose dexmedetomidine and esketamine during cesarean section provides a short-term improvement in early postpartum depressive symptoms, reduces intraoperative neuropsychiatric adverse events, and enhances maternal satisfaction, with a favorable maternal and neonatal safety profile.