Disposition of 14C-mescaline by rabbit lung.
Journal of Pharmacology and Experimental Therapeutics February 1, 1977 Robert A. Roth, Jan Roth, C. N. Gillis 17 citations
Rabbit lung tissue metabolizes mescaline four times more actively than liver or kidney tissue, while brain and plasma have little capacity to break it down. The metabolism is inhibited by semicarbazide. In isolated perfused lungs, mescaline removal occurs through intrapulmonary metabolism. Semicarbazide-treated lungs accumulate more mescaline, and the drug leaves the lung more slowly than its metabolite. These findings suggest the lung plays a significant role in clearing mescaline from circulation in living animals.