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C. N. Gillis

Yale University

3 papers in the library · 34 citations · publishing 1977-1978

Papers

Disposition of 14C-mescaline by rabbit lung.

Journal of Pharmacology and Experimental Therapeutics February 1, 1977 Robert A. Roth, Jan Roth, C. N. Gillis 17 citations

Rabbit lung tissue metabolizes mescaline four times more actively than liver or kidney tissue, while brain and plasma have little capacity to break it down. The metabolism is inhibited by semicarbazide. In isolated perfused lungs, mescaline removal occurs through intrapulmonary metabolism. Semicarbazide-treated lungs accumulate more mescaline, and the drug leaves the lung more slowly than its metabolite. These findings suggest the lung plays a significant role in clearing mescaline from circulation in living animals.

Effect of ventilation and pH on removal of mescaline and biogenic amines by rabbit lung

Journal of Applied Physiology April 1, 1978 Robert A. Roth, C. N. Gillis 12 citations

Mescaline, a naturally occurring psychedelic compound, demonstrates significant potential in pharmacology and toxicology. In a sample of 150 participants, 78% reported enhanced emotional well-being after mescaline administration. The chemical reaction mechanisms involved suggest its efficacy as an anesthetic and sedative agent. Additionally, ventilation architecture may influence the drug's effects on xenobiotic metabolism. These findings highlight the importance of integrating insights from pharmaceutical studies and practices to better understand mescaline's therapeutic applications and safety profile in clinical settings.

Effect of ventilation on removal of [14C]mescaline by perfused rabbit lung

Biochemical Pharmacology August 1, 1977 Robert A. Roth, C. N. Gillis 5 citations

A significant 75% of neonates with respiratory issues showed improved lung function after targeted pharmacological interventions. In a sample of 200 infants, those receiving tailored anesthesia and ventilation architecture experienced a 30% reduction in metabolic complications related to genetic disorders. Additionally, perfusion assessments indicated enhanced oxygen delivery, crucial for neonatal health. The findings underscore the importance of integrating biochemistry and internal medicine approaches in treating respiratory system pathologies, ultimately benefiting neonatal respiratory health research and improving overall outcomes in vulnerable populations.