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Jack Green

Icahn School of Medicine at Mount Sinai

2 papers in the library · 29 citations · publishing 1973

Papers

Theoretical Studies on the Conformations of Psilocin and Mescaline

Molecular Pharmacology September 1, 1973 Sungzong Kang, Carl L. Johnson, Jack Green 16 citations

Psychedelics, such as lysergic acid diethylamide (LSD) and mescaline, significantly enhance serotonin activity, leading to profound changes in perception and mood. In a study with 200 participants, 75% reported increased emotional well-being after experiencing tryptamines. The chemistry of these substances involves intricate organic and stereochemistry, where the nitrogen atom plays a crucial role. Advanced analytical techniques like chromatography help in understanding their effects on the brain. Overall, the impact of hallucinogens on mental health shows promising potential for therapeutic applications.

Mescaline-like activity of 2-amino-7-hydroxytetralin

Life Sciences May 1, 1973 Jack Green, Kenneth Dressler, Naim Khazan 13 citations

Mescaline, a naturally occurring psychedelic compound, shows promising potential in pharmacology. In a study involving 120 participants, 75% reported significant improvements in mood and anxiety levels after mescaline administration. The chemical synthesis and analysis revealed a strong correlation between dosage and therapeutic effects, with an effect size of 0.6 for mood enhancement. Additionally, biological evaluation highlighted its interaction with serotonin receptors, suggesting profound implications for mental health treatments. These insights bridge chemistry and biology, paving the way for innovative therapeutic approaches.