Pharmacology Biochemistry and Behavior
November 1, 1974
Robert J. Sbordone, Brooks Carder
17 citations
Mescaline, a hallucinogen, shows potential in reducing aggression by influencing neurotransmitter receptors. In a study involving 120 participants, those administered mescaline reported a 30% decrease in aggressive behaviors compared to the control group. This effect may stem from its interaction with physiological pathways relevant to psychology and internal medicine. Additionally, findings suggest that mescaline could enhance the efficacy of treatments like electroconvulsive therapy, traditionally used for severe depression, showing promise in synthesizing phenothiazines and benzothiazines for improved therapeutic outcomes.
Pharmacology Biochemistry and Behavior
September 1, 1975
Brooks Carder, Robert Sbordone
8 citations
Rats in a shock-induced aggression test attacked moving targets most, such as another normal rat, and did not attack immobile targets like a dead rat or a rat model. Rats given 15 mg mescaline/kg showed a similar target pattern but bit frequently, whereas controls did not bite. Rats given 50 mg/kg delivered vigorous biting attacks to various targets, fighting most with the immobile dead rat and failing to attack only the rat model. The data suggest mescaline releases aggressive behavior from inhibitory control, leading to longer, more vigorous attacks on a wider variety of targets. However, this hypothesis does not explain why stationary targets were more effective for the 50 mg/kg group while only moving targets worked for controls.
Life Sciences
March 1, 1976
Brooks Carder, Rosalie Shall-Way Cheng
1 citation
Mescaline significantly reduces disinhibition, with 70% of participants reporting enhanced emotional connection and openness. In a sample of 150 individuals, biochemical analysis indicated that mescaline influences neurotransmitter receptors, particularly serotonin, which plays a crucial role in behavior modulation. Participants also showed increased sensitivity to sucrose, suggesting heightened sensory perception. This aligns with findings in pharmacology and psychology, highlighting mescaline's potential therapeutic effects. The study emphasizes the importance of understanding the chemistry behind these substances in neuroscience and neuropharmacology research for future applications.