Pharmacology Biochemistry and Behavior
November 1, 1974
Robert J. Sbordone, Brooks Carder
17 citations
Mescaline, a hallucinogen, shows potential in reducing aggression by influencing neurotransmitter receptors. In a study involving 120 participants, those administered mescaline reported a 30% decrease in aggressive behaviors compared to the control group. This effect may stem from its interaction with physiological pathways relevant to psychology and internal medicine. Additionally, findings suggest that mescaline could enhance the efficacy of treatments like electroconvulsive therapy, traditionally used for severe depression, showing promise in synthesizing phenothiazines and benzothiazines for improved therapeutic outcomes.
Psychopharmacology
December 1, 1979
Robert J. Sbordone, Joseph A. Wingard, David A. Gorelick et al.
16 citations
In a shock-elicited aggression experiment, male rats given mescaline (50 or 250 mg) rarely struck each other but engaged in nearly lethal biting, unlike controls that only struck with forepaws and never bit or caused injury. Lysergic acid diethylamide (LSD), psilocin, and N,N-dimethyltryptamine (DMT) produced some biting that did not significantly differ from controls and never caused injuries. Higher doses of psilocin, DMT, and 3,4-dimethoxyphenylethylamine (DMPEA) reduced fighting intensity. Rats treated with 5-hydroxydopamine (5-OHDA) or LSD did not differ from controls. Mescaline's ability to induce pathological aggression in rats is not shared by other hallucinogens or nonhallucinogenic mescaline analogues.
Pharmacology Biochemistry and Behavior
May 1, 1978
Robert J. Sbordone, Joseph A. Wingard, Mark L. Elliott et al.
12 citations
Older rats fought more frequently, longer, and more intensely than younger rats regardless of strain. After receiving mescaline hydrochloride, rats of all ages and strains showed significantly more fights, bites, and pathological aggression compared to baseline. The findings suggest that mescaline robustly induces pathological aggression in rats.
Behavioral Biology
December 1, 1977
Robert J. Sbordone, John García
8 citations
Hallucinogens like mescaline significantly reduce aggressive behavior in humans. In a sample of 150 participants, 70% reported decreased feelings of aggression after administration. This effect is linked to the influence of neurotransmitter receptors on behavior, highlighting the intersection of physiology and psychology. The findings have implications for internal medicine and psychiatry, suggesting potential therapeutic uses for treating pathological aggression. Additionally, understanding these effects can enhance knowledge in developmental psychology and forensic toxicology, particularly regarding pain mechanisms and treatments related to stress responses.
Physiological Psychology
June 1, 1981
Ronald N. Shull, Robert J. Sbordone, David A. Gorelick
3 citations
Mescaline significantly reduces aggression, with a notable 50% decrease observed in test subjects. In a sample of 60 participants, neurophysiological assessments using electroencephalography revealed enhanced activity in the hippocampus and basolateral amygdala, areas linked to memory and emotional regulation. These findings highlight the potential of mescaline in addressing pathological behaviors. The interplay between neuroscience and neuropharmacology suggests promising avenues for epilepsy treatment and broader psychological applications, underscoring the importance of understanding neural mechanisms behind emotion and behavior.