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Joseph A. Wingard

University of California, Los Angeles

2 papers in the library · 28 citations · publishing 1978-1979

Papers

Severe aggression in rats induced by mescaline but not other hallucinogens

Psychopharmacology December 1, 1979 Robert J. Sbordone, Joseph A. Wingard, David A. Gorelick et al. 16 citations

In a shock-elicited aggression experiment, male rats given mescaline (50 or 250 mg) rarely struck each other but engaged in nearly lethal biting, unlike controls that only struck with forepaws and never bit or caused injury. Lysergic acid diethylamide (LSD), psilocin, and N,N-dimethyltryptamine (DMT) produced some biting that did not significantly differ from controls and never caused injuries. Higher doses of psilocin, DMT, and 3,4-dimethoxyphenylethylamine (DMPEA) reduced fighting intensity. Rats treated with 5-hydroxydopamine (5-OHDA) or LSD did not differ from controls. Mescaline's ability to induce pathological aggression in rats is not shared by other hallucinogens or nonhallucinogenic mescaline analogues.

DOI: 10.1007/bf00428319 Mescaline Lysergic acid diethylamide Hallucinogen Biting +3

Mescaline produces pathological aggression in rats regardless of age or strain

Pharmacology Biochemistry and Behavior May 1, 1978 Robert J. Sbordone, Joseph A. Wingard, Mark L. Elliott et al. 12 citations

Older rats fought more frequently, longer, and more intensely than younger rats regardless of strain. After receiving mescaline hydrochloride, rats of all ages and strains showed significantly more fights, bites, and pathological aggression compared to baseline. The findings suggest that mescaline robustly induces pathological aggression in rats.

DOI: 10.1016/0091-3057(78)90385-4 Mescaline Aggression Pathological Biting +3