Synthesis of Phenethylamines Related to Mescaline as Possible Psychotomimetic Agents1
Journal of Medicinal Chemistry May 1, 1963 Orrie M. Friedman, Krishnan Parameswaran, Sumner Burstein 14 citations
Several new phenethylamine compounds structurally related to mescaline were synthesized and tested for psychotomimetic activity in animals. The synthesis involved introducing sulfur and phosphorus substituents into the phenethylamine backbone. Some of the new compounds produced behavioral effects in animals similar to those of mescaline, suggesting they may act as hallucinogens. The work aimed to explore how chemical modifications to the mescaline structure affect psychoactive potency.