Structure-activity studies on hallucinogenic amphetamines using molecular connectivity
Journal of Medicinal Chemistry December 1, 1977 Lemont B. Kier, Lowell H. Hall 64 citations
A series of ring-substituted hallucinogenic amphetamines was analyzed using molecular connectivity, and a correlating equation was found between potency and connectivity terms. The equation allows interpretation of structure-activity relationships (SAR) and can predict potency for amphetamines not in the original list, as well as for mescalines and tryptamines.