A STEREOTYPED RESPONSE INDUCED BY MESCALINE IN MICE AS A MEANS OF INVESTIGATING THE PROPERTIES OF DRUGS ACTING ON THE CNS
Journal of Pharmacy and Pharmacology September 1, 1958 G Maffii, E Soncin 8 citations
Mescaline induces a stereotyped response in mice, measured as spontaneous activity in special cages. Chlorpromazine most specifically blocks this response. Promazine, hexobarbitone, and pentobarbitone also reduce the effect at doses that do not impair motor function, while phenobarbitone has little effect. Meprobamate, mephenesin, a thiadiazole derivative (L 1458), and azacyclonol do not produce specific antagonistic effects at non-paralyzing doses. Atropine does not significantly influence the response, but morphine enhances it.