Fluorescence Polarization Immunoassay Detection of Amphetamine, Methamphetamine, and Illicit Amphetamine Analogues*
Journal of Analytical Toxicology January 1, 1993 John T. Cody, R H Schwarzhoff 54 citations
Two commercial immunoassay reagents, Abbott's Amphetamine/Methamphetamine II and Amphetamine Class, were tested for their ability to detect a wide range of amphetamine-related compounds, including stereoisomers, metabolites, and illicit analogues such as MDMA, MDA, and mescaline, at concentrations from 100 to 100,000 ng/mL. The Amphetamine/Methamphetamine II reagent showed better overall performance, especially for detecting over-the-counter medications, while the Amphetamine Class reagent did not improve detection of amphetamine, methamphetamine, or illicit analogues. Some illicit analogues were reliably detected, but many others were not. The Amphetamine Class reagents are a poor choice unless detecting over-the-counter compounds is specifically needed.