Mescaline‐Spikes and Amino Acids in the Cortex of Cats Pretreated with Caffeine and Pentetrazol
Epilepsia September 1, 1970 C Pintilie, N Mison-Crighel, E Crighel 1 citation
In cats pretreated with nonconvulsant doses of pentetrazol or caffeine, a spiking focus induced by topical mescaline appeared earlier, with more frequent and irregular spikes, and in some caffeine-pretreated animals short spike discharges reminiscent of focal seizures were observed. The mescaline spikes altered free amino acid levels throughout the neocortex differently in pretreated versus untreated animals. Glycine increased significantly with either pretreatment; GABA increased significantly only with pentetrazol; alanine increased and arginine decreased only with pentetrazol. In untreated animals, glutamic acid, GABA, and alanine decreased.