SYNTHESIS OF N-(HALOGENATED) BENZYL ANALOGS OF SUPERPOTENT SEROTONIN LIGANDS
Journal of the Chilean Chemical Society September 1, 2014 Cristián Tirapegui, Miguel A Toro-Sazo, Bruce K. Cassels 1 citation
A group of extremely potent designer drugs called the NBOMe series, which are N-benzylated phenylethylamines, has emerged. While their high affinity for 5-HT2 serotonin receptors is well documented, the molecular basis of their potency and selectivity is not well understood. In a project evaluating halogen bonds in monoaminergic ligand binding, researchers synthesized new phenylethylamine and tryptamine derivatives with bromine atoms in their N-benzyl moiety. This work reports the synthesis of these compounds for further pharmacological study.