A glassy carbon electrode modified with an ionic liquid and tetraruthenated zinc porphyrin improves the voltammetric detection of N,N-dimethyltryptamine (DMT) compared to an unmodified electrode. The modified electrode achieves a low detection limit of 1.75 µM, a short response time, a satisfactory linear concentration range, and very good stability and reproducibility. This method offers a feasible and inexpensive way to detect DMT in water and has potential for detecting DMT in urine.
A group of extremely potent designer drugs called the NBOMe series, which are N-benzylated phenylethylamines, has emerged. While their high affinity for 5-HT2 serotonin receptors is well documented, the molecular basis of their potency and selectivity is not well understood. In a project evaluating halogen bonds in monoaminergic ligand binding, researchers synthesized new phenylethylamine and tryptamine derivatives with bromine atoms in their N-benzyl moiety. This work reports the synthesis of these compounds for further pharmacological study.