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Clara Cestonaro

Legal Medicine and Toxicology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.

2 papers in the library · 2 citations · publishing 2025

Papers

Infant Death due to Cannabis Ingestion.

Drug testing and analysis May 21, 2025 Donata Favretto, Antonello Cirnelli, Roberto Pertile et al. 2 citations

A child died hours after ingesting a cork-colored, earth-like substance. At the hospital, the child had trouble walking, balancing, and staying conscious, and needed intubation for breathing difficulty, receiving fentanyl and ketamine. Autopsy showed congestion in multiple organs. Toxicological tests on blood, urine, bile, organs, stomach contents, and hair detected cannabinoids, ketamine, norketamine, and fentanyl in emergency room blood; postmortem samples also contained cannabinoids. Hair analysis revealed THC, CBD, CBN, methadone, cocaine, morphine, and other drugs. Stomach contents had traces of cannabis. Acute cannabis intoxication amid chronic exposure to multiple drugs was deemed responsible for the death. Cases of intoxication are increasing with cannabis legalization, but data on young children remain scarce.

Psychological and neuropsychological effects of MDMA use during adolescence: a structured review.

Frontiers in psychiatry January 1, 2025 Rocco Miazzi, Clara Cestonaro, Silvia Righetto et al.

Adolescent MDMA use is linked to psychological disturbances such as increased depression, anxiety, suicidal ideation, and attempts, as well as neuropsychological deficits in memory, attention, and executive functioning. Neuroimaging evidence suggests MDMA disrupts serotonergic pathways, potentially causing persistent brain changes. The review synthesizes 14 human studies but notes methodological limitations like small sample sizes, high rates of polydrug use, and lack of longitudinal designs, complicating causal conclusions. The findings underscore the need for targeted prevention and harm reduction for adolescents.