Oral Glutamatergic Augmentation for Trauma-Related Disorders with Fluoxetine- / Bupropion- Potentiated Dextromethorphan ± Piracetam: A Four-Patient Case Series
Research Square November 25, 2025 Nai‐kong V. Cheung 1 citation
A brief oral regimen combining dextromethorphan with fluoxetine, sometimes plus piracetam or bupropion, produced rapid and lasting remission in four patients with hard-to-treat trauma-related disorders, including somatic PTSD, bereavement-related PTSD, adolescent depression, and complex PTSD with bipolar II and borderline features. Within days to weeks, intrusive memories, rumination, somatic pain, and disability sharply declined, with no dissociation, hypertension, or mania. The findings extend the ketamine/Auvelity treatment framework to trauma-spectrum illnesses and support controlled trials of low-cost NMDA–AMPA modulators for PTSD prevention and treatment.