Psychopharmacology
January 1, 2012
Michael E. Ballard, David A. Gallo, Harriet Wit
38 citations
Amphetamine (AMP) improves true memory for studied words, while THC impairs it, but neither drug significantly changes the tendency to falsely remember nonstudied words compared to placebo. Across participants, the drugs' effects on true memory correlated positively with their effects on false memory, suggesting that encoding processes influenced by these drugs similarly affect both accurate and false recollection. These results come from two within-subjects, double-blind experiments using the Deese/Roediger–McDermott illusion to test recognition memory two days after drug administration.
bioRxiv (Cold Spring Harbor Laboratory)
May 24, 2022
Manoj K. Doss, Jason Samaha, Frederick S. Barrett et al.
6 citations
preprint
Different classes of psychoactive drugs—sedatives, dissociatives, psychedelics, stimulants, and cannabinoids—each produce unique patterns of effects on the conscious processes underlying episodic memory, depending on whether they act during encoding, consolidation, or retrieval. Reanalyzing confidence data from 10 published datasets (28 drug conditions) with signal detection models, the authors found that all drugs except stimulants impaired recollection when given at encoding; sedatives, dissociatives, and cannabinoids also impaired familiarity at encoding. Psychedelics at encoding enhanced familiarity and did not affect metamemory, while dissociatives and cannabinoids tended to enhance metamemory. Stimulants enhanced metamemory at encoding and retrieval but impaired it at consolidation. These distinct profiles may help explain drug-specific subjective phenomena such as sedative-induced blackouts or psychedelic déjà vu.