Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice
Translational Psychiatry August 11, 2022 Nicole Fadahunsi, Jens Lund, Alberte Wollesen Breum et al. 47 citations
A single dose of psilocybin substantially alters the prefrontal cortex transcriptome in mice but has no acute or long-lasting effects on food intake or body weight in diet-induced obese mice or in genetic mouse models of obesity. Sub-chronic microdosing also has no metabolic effects, does not augment GLP-1-induced weight loss, and does not enhance diet-induced weight loss. A single high dose reduces sucrose preference but fails to counter binge-like eating behavior. These preclinical data discourage clinical investigation, though nuances in psychedelic drug action may require human evaluation.