Psilocybin may become a legal medicinal drug due to growing evidence of its efficacy for mental health disorders. This work tested the validity of a model of extra-pharmacological factors—set, setting, and intention—in predicting attitudes toward psilocybin. Two hundred nineteen participants completed online measures of personality and the Attitudes Toward Psilocybin scale. A model including a positive set, openness to experience, and lower extraversion significantly predicted attitudes. The findings support the model and suggest that a psychological suitability test could help determine whether psilocybin prescription is appropriate.
A model of extra-pharmacological factors—set, setting, and intention—predicts attitudes toward psilocybin, supporting the idea that a psychological suitability test could help determine whether psilocybin is an appropriate treatment. In 219 adults, openness to experience, extraversion, and set significantly predicted scores on the Attitudes Towards Psilocybin scale, which showed good reliability and validity. The sample was evenly split between those with and without prior psychedelic use. The findings suggest that non-drug factors matter for medicinal psilocybin decisions.