Total Recall: Lateral Habenula and Psychedelics in the Study of Depression and Comorbid Brain Disorders
International Journal of Molecular Sciences September 7, 2020 Matas Vitkauskas, Ajay S. Mathuru 4 citations
Depression affects millions worldwide. Recent research explores the lateral habenula's role in depression and the potential of psychedelics like psilocybin and ketamine as treatments. Clinical trials are testing deep brain stimulation of the habenula and psychedelic therapies targeting the serotonergic system. Early results are promising but require cautious optimism; more animal studies in naturalistic settings, larger human trials with better neuroimaging, and understanding of genetic and molecular factors underlying comorbid disorders are needed. Advances in cerebral organoids may accelerate progress. This review covers developments in these areas and discusses future directions.