[Interventional psychiatric procedures and novel substances for the treatment of affective disorders: An overview and outlook].
Therapeutische Umschau. Revue therapeutique April 1, 2025 Tobias Bracht, Daniela Hubl, Kristina Adorjan et al. 1 citation
For patients with difficult-to-treat depression who do not respond to at least two antidepressant trials, remission rates are significantly lower than the 67% seen with initial or secondary pharmacological treatment. Brain stimulation procedures and novel substances offer innovative and effective options to complement standard therapies. This overview covers repetitive transcranial magnetic stimulation, electroconvulsive therapy, ketamine/esketamine, transcranial direct current stimulation, deep brain stimulation, and psychedelic-assisted psychotherapy, with an outlook on individualized, procedure-specific indications.