Therapeutische Umschau. Revue therapeutique

ISSN 0040-5930

2 papers in the library · 1 citation · publishing 2025-2026

Papers

[Interventional psychiatric procedures and novel substances for the treatment of affective disorders: An overview and outlook].

Therapeutische Umschau. Revue therapeutique April 1, 2025 Tobias Bracht, Daniela Hubl, Kristina Adorjan et al. 1 citation

For patients with difficult-to-treat depression who do not respond to at least two antidepressant trials, remission rates are significantly lower than the 67% seen with initial or secondary pharmacological treatment. Brain stimulation procedures and novel substances offer innovative and effective options to complement standard therapies. This overview covers repetitive transcranial magnetic stimulation, electroconvulsive therapy, ketamine/esketamine, transcranial direct current stimulation, deep brain stimulation, and psychedelic-assisted psychotherapy, with an outlook on individualized, procedure-specific indications.

DOI: 10.23785/TU.2025.02.005 Full text Treatment-resistant depression Electroconvulsive therapy ect Ketamine/esketamine Depression therapy innovations +3

[Pharmacological post-acute treatment of alcohol use disorder: Established strategies and innovative approaches].

Therapeutische Umschau. Revue therapeutique February 1, 2026 Patrik Roser

Alcohol use disorders are a major contributor to the global disease burden. After the acute withdrawal phase, the main goal of post-acute treatment is long-term abstinence, though reducing consumption is also recognized as an intermediate aim. In Switzerland, four medications—acamprosate, naltrexone, nalmefene, and disulfiram—are approved for this phase and have well-established efficacy in reducing relapse risk, drinking days, and overall alcohol consumption. Off-label use of baclofen, topiramate, and gabapentin lacks sufficient evidence of effectiveness. Emerging treatments such as cannabidiol, psilocybin, and glucagon-like peptide-1 receptor agonists show promising potential that requires further clinical confirmation. Pharmacological interventions can improve patient outcomes, reduce inpatient treatment needs, and lower healthcare costs.

DOI: 10.23785/tu.2026.01.006 Full text Dependence Alcohol Medication Post-acute treatment +1