The effects of psilocybin on psychological distress in cancer patients: a systematic review and meta-analysis
BMC Psychology January 2, 2026 Reza Moshfeghinia, Sara Mostafavi, Kimia Jazi et al. 2 citations
Psilocybin may reduce depressive symptoms in cancer patients, with mixed effects on anxiety and time-dependent improvements in spiritual well-being and, in single-arm data, quality of life. However, due to the small number of studies, high heterogeneity, challenges with blinding and expectancy, and frequent co-intervention with psychotherapy, these findings are preliminary. Larger, rigorously blinded trials are needed to determine clinical effectiveness and safety.