620. IDENTIFICATION OF BLOOD BIOMARKERS OF PSILOCYBIN-ASSISTED THERAPY TREATMENT RESPONSE FOR GENERALISED ANXIETY DISORDER
The International Journal of Neuropsychopharmacology August 1, 2025 Andrew S. Gibbons, Paul Liknaitzky, Suresh Sundram
Generalised Anxiety Disorder (GAD) is often treated with psilocybin-assisted therapy (PAT), but only about 44% of participants respond. This multi-omic study compared blood samples from 11 responders and 13 non-responders after a 6-week PAT regime. Five genes were differentially expressed between groups, including CTXN2-AS1 and HLA-V. A panel of four genes (CTXN2-AS1, DUT-AS1, HLA-V, and PARP16) could distinguish 45% of responders from all other participants. These findings suggest potential blood biomarkers for predicting PAT response in GAD, though validation in larger cohorts is needed.