Overcoming Depression with 5-HT2A Receptor Ligands
International Journal of Molecular Sciences December 21, 2021 Agata Zięba, Piotr Stępnicki, Dariusz Matosiuk et al. 55 citations
Depression affects millions globally and current treatments are not fully curative. Recent insights into the structure and function of the serotonin 2A (5-HT2A) receptor have enabled the design of new antidepressant compounds. This review summarizes the role of 5-HT2A receptor signaling modulators in depression treatment, describes the receptor's structural and physiological features, and overviews recent virtual screening campaigns that identified novel 5-HT2A receptor ligands, along with data on newly synthesized ligands acting through this protein.