A paper-based electrochemical device made from watercolor paper, graphite pencil, and silver paint can detect lysergic acid diethylamide (LSD) in seized samples. The device uses square wave voltammetry and achieves detection and quantification limits of 0.38 and 1.27 μmol/L, respectively. Its performance matches that of a commercial screen-printed carbon electrode, and it successfully distinguished LSD from MDMA and methamphetamine. Recovery from seized samples was less than 10%. The approach offers a low-cost, portable alternative for forensic drug analysis.
A simple, fast, and sensitive voltammetric method using a glassy carbon electrode and an aqueous solution of KClO4 as supporting electrolyte quantifies LSD in seized blotters. The anodic peak at 0.88 V vs. Ag/AgCl is proportional to LSD concentration, with detection and quantification limits of 0.987 and 3.29 µmol L⁻¹, respectively, enabling detection at µg per mL of extraction solution. The method also detects 25H-NBOMe, a compound with psychoactive effects similar to LSD. This less polluting methodology offers a practical tool for forensic analysis of these substances.