Influence of LSD-25 on optically evoked potentials in the nonanesthetized rabbit
American Journal of Physiology-Legacy Content June 1, 1959 Werner P. Koella, C.h. Wells 12 citations
Intravenous LSD-25 alters brain responses to visual stimuli in rabbits over many hours. Moderate doses (35 µg per animal) enhanced the size of electrically recorded cortical potentials for over six hours, with a triphasic pattern in amplitude over time. The drug also shortened the latency of these potentials by about 10%. LSD-25 markedly reduced the natural variability of both the amplitude and latency of the potentials for one to three hours after injection, indicating a stabilizing effect on neural responses.