Gas Liquid Chromatographic and Mass Spectrometric Studies on Trimethylsilyl Derivatives of N-Methyl- and N,N-Dimethyltryptamines
Journal of Chromatographic Science August 1, 1971 N. Narasimhachari, J. Spaide, Bh Heller 22 citations
N,N-dimethyltryptamines (DMT, 5-OMe-DMT, and bufotenin) were fully converted to trimethylsilyl derivatives with the TMS group attached to the indolic nitrogen. Gas-liquid chromatography data for these derivatives and mass spectrometry data from combined GC-MS analysis are reported. Secondary amines N-methyltryptamine and N-methylserotonin formed multiple derivatives, with the indolic NH reacting more readily than the secondary amino NH. Primary amines reacted with carbon disulfide to produce isothiocyanates that exhibit good gas chromatography properties and are well suited for GC-MS studies.