ISSN 0021-9665
6 papers in the library · 118 citations · publishing 1971-2018
Journal of Chromatographic Science January 1, 1973 John D. Wittwer, J. H. Kluckhohn 46 citations
A procedure to analyze d-lysergic acid diethylamide (LSD), the most widely abused hallucinogenic drug, incorporates a simple preliminary extraction step to isolate LSD from illicit preparations before analysis by high-speed liquid chromatography.
Journal of Chromatographic Science August 1, 1971 N. Narasimhachari, J. Spaide, Bh Heller 22 citations
N,N-dimethyltryptamines (DMT, 5-OMe-DMT, and bufotenin) were fully converted to trimethylsilyl derivatives with the TMS group attached to the indolic nitrogen. Gas-liquid chromatography data for these derivatives and mass spectrometry data from combined GC-MS analysis are reported. Secondary amines N-methyltryptamine and N-methylserotonin formed multiple derivatives, with the indolic NH reacting more readily than the secondary amino NH. Primary amines reacted with carbon disulfide to produce isothiocyanates that exhibit good gas chromatography properties and are well suited for GC-MS studies.
Journal of Chromatographic Science January 1, 1973 Ellen M. Faed, W. R. Mcleod 19 citations
A method for detecting lysergide (LSD-25) in urine is described, using solvent extraction and thin-layer chromatography. The procedure concentrates the drug from a 25 ml urine sample, hydrolyzes it to iso-lysergic acid, and then extracts and chromatographs the product. The limit of detection is approximately 0.5 micrograms per milliliter of urine. The test is intended for routine screening in clinical or forensic settings.
Journal of Chromatographic Science November 15, 2018 Norbert Rácz, Júlia Nagy, Wen Jiang et al. 12 citations
Three hydrophilic interaction liquid chromatography (HILIC) charge modulated amide columns—iHILIC®-Fusion, iHILIC®-Fusion(+), and iHILIC®-Fusion(P)—were compared for separating hallucinogenic alkaloids (psilocin, psilocybin, and baeocystin) from an extract of a truffle-like fungus. Three modeling methods predicted retention times in isocratic separation as a function of mobile phase composition, pH, and temperature. All columns separated the two hallucinogenic alkaloids from each other and from matrix components, with most compounds achieving satisfactory resolution. The quadratic modeling approach best predicted chromatograms under predefined conditions, the exponential model performed worst, and multivariate data analysis fell between the two.
Journal of Chromatographic Science May 1, 1974 Albert R. Sperling 10 citations
A method for identifying LSD combines thin-layer chromatography and gas chromatography. For gas chromatographic identification, the trimethylsilyl derivative of LSD is prepared to enable detection.
Journal of Chromatographic Science May 1, 2007 A. L. Thigpen, J. Deruiter, Charles R. Clark 9 citations
Six regioisomeric methylenedioxyphenethylamines, including three known drugs of abuse (MDEA, MDMMA, MBDB) and their 2,3-methylenedioxy counterparts, have nearly identical mass spectra and cannot be distinguished by electron impact mass spectrometry alone. Differentiation requires derivatization to pentafluoropropionylamides (PFPA) or heptafluorobutrylamides (HFBA). Underivatized amines are not resolved on non-polar stationary phases but are separated on a more polar trifluoropropylmethyl polysiloxane (Rtx-200) or a permethylated beta-cyclodextran (Rtx-bDEX) column. The PFPA and HFBA derivatives of the 2,3-methylenedioxyphenethylamines elute before the corresponding 3,4-methylenedioxyphenethylamine derivatives on the Rtx-200 column.