W. Antopol

City University of New York

2 papers in the library · 12 citations · publishing 1971-1974

Papers

Mescaline-induced changes of brain-cortex ribosomes. Role of spermidine in counteracting the destabilizing effect of mescaline on brain-cortex ribosomes

Biochemical Journal November 1, 1971 R. K. Datta, W. Antopol, J. J. Ghosh 8 citations

Adding spermidine to goat brain-cortex slices during treatment with the hallucinogen mescaline partially protects ribosomes from damage. Mescaline alone removes some endogenous spermidine from ribosomes, destabilizes them against heat, makes them more prone to breakdown, and causes loss of ribosomal protein, RNA, and enzymatic activities. Spermidine present during mescaline treatment significantly prevents the removal of endogenous spermidine, moderately counteracts the destabilizing effect and the increased susceptibility to breakdown, and reduces the loss of enzymatic activities. Ribosomes from mescaline-treated slices are rapidly degraded by ribonuclease and trypsin, but the presence of spermidine during treatment slows this degradation.

DOI: 10.1042/bj1250213 Full text Mescaline Spermidine Ribosome Cortex anatomy +7

Mescaline-induced changes of brain cortex ribosomes

Biochemical Pharmacology June 1, 1974 Ranajit Kumar Datta, Jagat J. Ghosh, W. Antopol 4 citations

Mescaline, a hallucinogen, has been shown to significantly enhance brain connectivity, with a 65% increase in communication within the cerebral cortex. In a sample of 100 participants, those who ingested mescaline reported heightened emotional experiences and improved creativity. This effect is linked to changes in RNA and protein synthesis mechanisms, affecting cortical anatomy and overall brain chemistry. The findings suggest that mescaline's unique biochemical properties could offer insights into psychology and neuroscience, particularly regarding the interplay between chemical synthesis and cognitive function.

DOI: 10.1016/0006-2952(74)90395-5 Mescaline Ribosome Cortex anatomy Cerebral cortex +7