Biochemical Journal
August 1, 1954
Joyce L. Lewis, H. Mcilwain
29 citations
In separated mammalian cerebral tissues, ergot derivatives, mescaline, and dibenamine each altered tissue metabolism. The substances affected the respiration and glycolysis of the tissues, with the specific effects depending on the compound and concentration used. The findings indicate that these agents can directly influence the metabolic activity of brain tissue.
Biochemical Journal
May 1, 1970
R. K. Datta, J. J. Ghosh
12 citations
Mescaline sulfate causes ribosomes in goat brain-cortex slices to break down, releasing protein, RNA, acid-soluble nucleotides, and ninhydrin-positive materials, and leads to a loss of ribosomal enzyme activities. Ribosomes from treated slices also degrade more rapidly when exposed to trypsin and ribonuclease. However, mescaline does not change the chemical or nucleotide composition or the ultraviolet-absorption characteristics of the ribosomal particles.
Biochemical Journal
November 1, 1971
R. K. Datta, W. Antopol, J. J. Ghosh
8 citations
Adding spermidine to goat brain-cortex slices during treatment with the hallucinogen mescaline partially protects ribosomes from damage. Mescaline alone removes some endogenous spermidine from ribosomes, destabilizes them against heat, makes them more prone to breakdown, and causes loss of ribosomal protein, RNA, and enzymatic activities. Spermidine present during mescaline treatment significantly prevents the removal of endogenous spermidine, moderately counteracts the destabilizing effect and the increased susceptibility to breakdown, and reduces the loss of enzymatic activities. Ribosomes from mescaline-treated slices are rapidly degraded by ribonuclease and trypsin, but the presence of spermidine during treatment slows this degradation.
Biochemical Journal
May 1, 1970
R. K. Datta, J. J. Ghosh
8 citations
Mescaline sulfate reduces the hydrogen-bonded structure of ribosomal RNA in goat brain-cortex slices. The hyperchromic effect of heating and formaldehyde reaction showed that ribosomal total RNA from treated slices had a smaller proportion of hydrogen-bonded structure than RNA from untreated slices. Mescaline also appeared to lower the hydrogen-bonded structure specifically in ribosomal 28S RNA of brain-cortex tissue.