Actions of Mescaline on Isolated Rat Atria
Journal of Pharmaceutical Sciences July 1, 1977 Peter K. S. Siegl, Raymond F. Orzechowski 2 citations
Mescaline at concentrations of 5 x 10⁻⁴ and 1 x 10⁻³ M slowed the heart rate (negative chronotropic effect) and increased the force of contraction (positive inotropic effect) in isolated, spontaneously beating rat atria. When the atria were electrically paced at a constant rate, the increase in contraction force was greatly reduced, suggesting the force increase was secondary to the rate decrease. Pretreatment with histamine antagonists chlorpheniramine and metiamide did not consistently alter these responses.