6-Hydroxydopamine inhibits some effects of mescaline centrally administered to rabbits
Psychopharmacology June 1, 1977 Sergio Solbes Ferri, Roser Reina, C. Spadaro et al. 3 citations
In rabbits, the narcotic antagonist naloxone does not block pain relief (antinociception) caused by 100 micrograms per kilogram of mescaline injected into the brain, but pretreatment with 6-hydroxydopamine (6-OHDA) does prevent this effect. 6-OHDA also prevents the stereotyped behavior that follows central mescaline administration. Because 6-OHDA destroys nerve terminals that contain catecholamines, the findings suggest that catecholamines play a crucial role in the effects produced by the hallucinogen mescaline when given centrally to rabbits.