Development of tolerance to the antinociceptive effect of mescaline intraventricularly administered to rabbits
Psychopharmacology January 1, 1976 Sergio Solbes Ferri, A. Santagostino, P. C. Braga 6 citations
In conscious rabbits, acute intraventricular injection of mescaline at doses of 70, 100, and 150 micrograms per kilogram produced dose-dependent analgesia, measured by electrical stimulation of the tooth pulp. With daily administration of 100 micrograms per kilogram for five days, complete tolerance developed to this antinociceptive effect. Tolerance also developed to the behavioral effects of mescaline after repeated doses, except for a stuporous state, which became more pronounced as treatment continued. Acute mescaline caused EEG arousal; chronic treatment at 100 micrograms per kilogram progressively slowed the return of voltage to original levels. Comparing certain mescaline-induced effects with those of morphine suggests some shared biochemical and neural patterns.