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A. Santagostino

University of Milan

2 papers in the library · 10 citations · publishing 1976

Papers

Development of tolerance to the antinociceptive effect of mescaline intraventricularly administered to rabbits

Psychopharmacology January 1, 1976 Sergio Solbes Ferri, A. Santagostino, P. C. Braga 6 citations

In conscious rabbits, acute intraventricular injection of mescaline at doses of 70, 100, and 150 micrograms per kilogram produced dose-dependent analgesia, measured by electrical stimulation of the tooth pulp. With daily administration of 100 micrograms per kilogram for five days, complete tolerance developed to this antinociceptive effect. Tolerance also developed to the behavioral effects of mescaline after repeated doses, except for a stuporous state, which became more pronounced as treatment continued. Acute mescaline caused EEG arousal; chronic treatment at 100 micrograms per kilogram progressively slowed the return of voltage to original levels. Comparing certain mescaline-induced effects with those of morphine suggests some shared biochemical and neural patterns.

DOI: 10.1007/bf00427610 Mescaline Nociception Morphine Pharmacology +4

Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates

Psychopharmacology January 1, 1976 Sergio Solbes Ferri, A. Santagostino, Pier Carlo Braga 4 citations

Repeated administration of equipotent doses of morphine (10 mug/kg) and mescaline (100 mug/kg) directly into the brain ventricles of rabbits produces tolerance and cross-tolerance to their pain-blocking effects. Electrical recordings from various brain regions show that partial tolerance also develops to the electroencephalographic changes caused by chronic mescaline treatment. Comparing certain effects of mescaline with those of morphine suggests that the two drugs share some common biochemical and neural mechanisms.

DOI: 10.1007/bf00427611 Mescaline Morphine Nociception Cross-tolerance +6