Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates
Psychopharmacology January 1, 1976 Sergio Solbes Ferri, A. Santagostino, Pier Carlo Braga 4 citations
Repeated administration of equipotent doses of morphine (10 mug/kg) and mescaline (100 mug/kg) directly into the brain ventricles of rabbits produces tolerance and cross-tolerance to their pain-blocking effects. Electrical recordings from various brain regions show that partial tolerance also develops to the electroencephalographic changes caused by chronic mescaline treatment. Comparing certain effects of mescaline with those of morphine suggests that the two drugs share some common biochemical and neural mechanisms.