THE EFFECT OF AN ECTOSYLVIAN EPILEPTOGENIC FOCUS INDUCED BY TOPICAL APPLICATION OF MESCALINE ON NITROGENOUS COMPOUNDS IN THE NEOCORTEX OF CAT
Journal of Neurochemistry November 1, 1966 G Badiu, N Mison-Crighel 4 citations
Topical application of mescaline to the neocortex induced an epileptiform spiking focus and altered nitrogenous compounds across the entire cerebral cortex. Within two minutes, before spiking began, ammonia levels rose significantly in all neocortical areas, especially at the focus and the homolateral marginal gyrus; free amide nitrogen decreased and non-protein nitrogen increased throughout the cortex. At thirty minutes, during focus development, ammonia remained elevated with a slight decline, free amide nitrogen was reduced in all neocortical areas, and protein nitrogen decreased in both marginal gyri while lipid nitrogen fell in the focus and both marginal gyri.