Asian journal of psychiatry
June 1, 2025
Mingrui Chen, Jingyan Jin, Hongsheng Bi et al.
12 citations
NMDA receptors, a type of glutamate receptor, are central to neuroplasticity and are implicated in depression, where their dysfunction can cause neuronal damage and disrupt brain adaptability. Ketamine, an NMDA receptor antagonist, rapidly alleviates severe depression and suicidal thoughts within hours by reducing NMDA receptor activity and activating the mTOR pathway, but its use is limited by side effects like hallucinations and dependency. Esketamine, an FDA-approved variant, offers improved efficacy and fewer side effects. Other NMDA-modulating compounds, including memantine and rapastinel, are under investigation. Future research should focus on NMDA receptor molecular mechanisms to develop safer, more effective, and personalized depression treatments with longer-lasting effects.
AIDS care
January 1, 2025
Yan Wang, Carla J Berg, Yeycy Donastorg et al.
2 citations
Among female sex workers living with HIV in the Dominican Republic, greater mindfulness was linked to lower depression and HIV stigma, and higher antiretroviral therapy adherence both at the same time and at later time points. Higher mindfulness also showed contemporaneous associations with reduced at-risk alcohol use and higher viral suppression. The findings suggest that mindfulness instruction could help improve mental health and HIV outcomes in this population.
Noise & health
Tao Chen, Haolei Niu, Yan Wang
Adding five-element music therapy and mindfulness meditation to standard care reduces cancer-related fatigue, anxiety, and depression in patients with diffuse large B-cell lymphoma undergoing chemotherapy. In a retrospective study of 78 patients, those receiving the combined intervention showed lower physical, emotional, and cognitive fatigue; lower depression and anxiety scores; better sleep quality; longer sleep duration; improved treatment compliance; higher nursing satisfaction; and better overall quality of life compared with those receiving conventional care alone. The combination appears to be a useful non-drug adjunct in oncology care.