Ketamine-Assisted Psychotherapy for Treatment- Resistant Depression with Comorbid Post-Traumatic Stress Disorder in Veterans
Insight the psychological dimensions of society November 19, 2025 O. Orlov Aleksey, V. Zaika, O. Fitkalo
In an open-label naturalistic study, 27 Ukrainian veterans with treatment-resistant depression and PTSD symptoms received 1–4 ketamine infusions (0.5–1.0 mg/kg) paired with psychotherapy. Depression scores dropped significantly on the PHQ-9 and BDI (both p < .001, g = 1.20–1.31), and PTSD symptoms also decreased (PCL-M: p < .001, g = 1.10). Over half of participants achieved substantial improvement or remission, while 22–26% showed no change or slight worsening. Benefits lasted at least one month. No link was found between outcomes and age or therapist personality. The study adapted international guidelines for Ukraine's wartime context.