Skip to content

Insight the psychological dimensions of society

ISSN 2663-970X

2 papers in the library · 1 citation · publishing 2022-2025

Papers

Обґрунтування можливості використання психофармакотерапевтичних методів для подолання негативного впливу російської війни на психічне здоров’я населення

Insight the psychological dimensions of society July 12, 2022 Олег Вікторович Орлов 1 citation

At least 23.5 million Ukrainian citizens are at risk of mental health deterioration due to the war, with up to 20% facing moderate to severe conditions and about 70% mild cases. Psychedelic-assisted therapy (PAT) using MDMA, psilocybin, and ketamine is described as a breakthrough treatment in the US, being three times more effective than standard psychotherapy and twice as effective as standard medication for PTSD, with shorter treatment duration and similar safety. In pre-war Ukraine, work began on theoretical foundations and personnel training for PAT, but current outdated legislation—specifically a 2000 Cabinet resolution banning necessary psychotropic substances and a 2008 Health Ministry order not accounting for combined therapies—prevents its implementation. The authors recommend urgent legislative changes to reclassify MDMA, DMT, psilocybin, and psilocin and to establish expanded access programs.

Ketamine-Assisted Psychotherapy for Treatment- Resistant Depression with Comorbid Post-Traumatic Stress Disorder in Veterans

Insight the psychological dimensions of society November 19, 2025 O. Orlov Aleksey, V. Zaika, O. Fitkalo

In an open-label naturalistic study, 27 Ukrainian veterans with treatment-resistant depression and PTSD symptoms received 1–4 ketamine infusions (0.5–1.0 mg/kg) paired with psychotherapy. Depression scores dropped significantly on the PHQ-9 and BDI (both p < .001, g = 1.20–1.31), and PTSD symptoms also decreased (PCL-M: p < .001, g = 1.10). Over half of participants achieved substantial improvement or remission, while 22–26% showed no change or slight worsening. Benefits lasted at least one month. No link was found between outcomes and age or therapist personality. The study adapted international guidelines for Ukraine's wartime context.